研究揭示前扣帶皮層在氮麻醉下的過度運動中的作用

作者：小柯機器人 發(fā)布時間：2024/8/21 16:34:34

本期文章：《神經科學通報》：Online/在線發(fā)表

南通大學高永靜課題組揭示了前扣帶皮層在氮麻醉下的過度運動中的作用。2024年8月19日，《神經科學通報》雜志在線發(fā)表了這項成果。

研究人員報告了氮麻醉顯著增加了小鼠的運動活動，并且這種效應與壓力呈依賴關系。同時，氮麻醉引起了前扣帶皮層（ACC）和背內側紋狀體（DMS）神經元的顯著激活。值得注意的是，化學遺傳學抑制ACC神經元有效地抑制了過度運動。相反，化學遺傳學興奮ACC神經元降低了誘發(fā)過度運動所需的高壓閾值。

此外，ACC內的活動依賴性神經元的化學遺傳學抑制和基因剔除都減少了過度運動。進一步研究表明，ACC神經元投射到DMS，化學遺傳學抑制ACC-DMS投射減少了過度運動。最后，氮麻醉導致ACC和DMS內的局部場電位在θ頻段增加，α頻段減少。這些結果共同表明，ACC內的興奮性神經元及其對DMS的投射在調節(jié)氮麻醉誘導的過度運動中發(fā)揮了關鍵作用。

研究人員表示，氮麻醉是一種神經系統(tǒng)綜合癥，發(fā)生在個體接觸高壓氮氣時，導致運動、情緒和認知方面的異常。ACC在調節(jié)動機、認知和行動中具有重要作用，但其在氮麻醉誘導的過度運動中的具體作用及機制仍不清楚。

附：英文原文

Title: Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis

Author: Peng, Bin, Wu, Xiao-Bo, Zhang, Zhi-Jun, Cao, De-li, Zhao, Lin-Xia, Wu, Hao, Gao, Yong-Jing

Issue&Volume: 2024-08-19

Abstract: Nitrogen narcosis is a neurological syndrome that manifests when humans or animals encounter hyperbaric nitrogen, resulting in a range of motor, emotional, and cognitive abnormalities. The anterior cingulate cortex (ACC) is known for its significant involvement in regulating motivation, cognition, and action. However, its specific contribution to nitrogen narcosis-induced hyperlocomotion and the underlying mechanisms remain poorly understood. Here we report that exposure to hyperbaric nitrogen notably increased the locomotor activity of mice in a pressure-dependent manner. Concurrently, this exposure induced heightened activation among neurons in both the ACC and dorsal medial striatum (DMS). Notably, chemogenetic inhibition of ACC neurons effectively suppressed hyperlocomotion. Conversely, chemogenetic excitation lowered the hyperbaric pressure threshold required to induce hyperlocomotion. Moreover, both chemogenetic inhibition and genetic ablation of activity-dependent neurons within the ACC reduced the hyperlocomotion. Further investigation revealed that ACC neurons project to the DMS, and chemogenetic inhibition of ACC-DMS projections resulted in a reduction in hyperlocomotion. Finally, nitrogen narcosis led to an increase in local field potentials in the theta frequency band and a decrease in the alpha frequency band in both the ACC and DMS. These results collectively suggest that excitatory neurons within the ACC, along with their projections to the DMS, play a pivotal role in regulating the hyperlocomotion induced by exposure to hyperbaric nitrogen.

DOI: 10.1007/s12264-024-01278-z

Source: https://link.springer.com/article/10.1007/s12264-024-01278-z

期刊信息

Neuroscience Bulletin：《神經科學通報》，創(chuàng)刊于2006年。隸屬于施普林格·自然出版集團，最新IF：5.6

官方網(wǎng)址：https://link.springer.com/journal/12264

投稿鏈接：https://mc03.manuscriptcentral.com/nsb